EU 2018/782. Commission Regulation EU 2018/782 Establishing the methodological principles for the risk assessment and risk management recommendations referred to in Regulation (EC) No 470/2009. Comes into force 18th June. Regulation (EC) No 470/2009 lays down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin. This Regulation sets out the methodological principles for the scientific risk assessment and risk management recommendations referred to in Articles 6 and 7 of that Regulation that shall be applied by the European Medicines Agency when preparing opinions on the MRLs of pharmacologically active substances which may be permitted in food of animal origin under that Regulation.