The amended REACH annexes concerning skin and eye irritation and acute dermal toxicity have been published in the Official Journal of the European Union and will enter into force on 20 June. The REACH requirements for skin corrosion/irritation, serious eye damage/eye irritation, acute dermal toxicity and skin sensitisation are changing, making non-animal testing the default requirement. ECHA (European Chemical Agency) reminds registrants of their obligations to consider and, where possible, use alternative methods.